Asymmetric amplification for a trans-1,2-cyclohexadiamine ligand.(Organometallic chemistry)(Brief article)

The bis(triflylamide) 8 (Reaction 4) has been used extensively as a ligand in titanium-mediated additions of organozincs to aldehydes. This is the type of reaction that inspires chemists to search for non-linear effects. However, Kagan et al (Org Lett 2007, 9, 251) have shown the origin of the non-linear effect …